21,000 인간 단백질 - 진온바이오텍(geneon biotech)

단백질 결합 분석

인간 전체 단백질 중 90% 이상이 한 칩안에!

세계 최고 수준의 Proteomics 연구를 만나보세요.

가능 샘플: 항체, Serum/Plasma, 단백질, 케미컬 등

인간단백질칩 상
21,000 단백질 구성

인간의 약 22,000가지 유전자가 만드는 22,000가지 단백질 중, 90% 이상이
한 칩 안에 집적되었습니다. 이를 이용하여 샘플이 결합하는 인간단백질을
빠르고 정확하게 확인하실 수 있습니다.

PROTEINS LIST 다운로드

모든 단백질이
Dual-spots으로

칩 상의 모든 단백질은 Dual spots, 즉 동일한 두 스팟으로 구성되어있으며, 한 번의 실험으로도 double checking이 가능합니다.

160건 이상의 reference 논문

칩 상의 모든 단백질은 Dual spots, 즉 동일한 두 스팟으로 구성되어있으며, 한 번의 실험으로도 double checking이 가능합니다.

연구보고서 샘플 다운로드

샘플 유형별 적용 분야

항체 샘플

항체특이성 및 교차반응 테스트
(Antibody Specificity & Cross-reactivity Test)

바이오시밀러-오리지널의 약품
동등성 비교 테스트

인간 혈청

혈청 프로파일링 : 질병특이적 면역
반응연구

자가면역질환 연구, 약물 반응성
연구 등

단백질 샘플

단백질-단백질 결합(Protein-Protein Interactions) 실험

소분자 물질

DNA, RNA, Peptide, Chemical 등의
샘플의 Human Protein Interactome
구축

Reference

Antibody Specificity and Cross-reactivity

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Auto-antibody Biomarker Profiling

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Protein-Protein Interactions (PPIs)

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Kinase assays

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Other enzyme assays

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Nucleic Acid Binding

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Small molecule-Protein Interactions

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Other

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

연구서비스 수행과정

STEP 1.

연구 설계 및 NDA 작성

연구 컨설팅 및 학술 상담
비밀유지/물질이전 계약
전체 실험 스케줄 세팅

STEP 2. Microarray

preparation 및 샘플 전처리

Antigen specific peptides 계산
컨펌 후 각각의 Peptides 합성
Peptides Microarray 제조

STEP 3.

본실험 및 분석

샘플 송부 및 수령
샘플 전처리 및 컨디션 확인
Go Epitope Mapping 수행

STEP 4.

보고서 작성 및 송부

실험 결과 확인 및 데이터 마이닝
종합 연구보고서 작성
연구보고서 및 로데이터 송부

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