진온바이오텍(geneon biotech)

단백질 결합 분석

임상 샘플에 최적화된 인간 1,600가지 단백질칩

새로운 Biomarkers를 발견하세요!

가능 샘플: 항체, Serum/Plasma, 단백질, 케미컬 등

임상에 최적화된 ‘잘 만든’
단백질 1,600종!

Well-folded 1,600가지 단백질로 임상 샘플 내의 다양한
auto-antibody 결합을 확인하세요.

PROTEINS LIST 다운로드

모든 단백질이
Dual-spots으로

칩 상의 모든 단백질은 Dual spots, 즉 동일한 두 스팟으로 구성되어있으며, 한 번의 실험으로도 double checking이 가능합니다.

160건 이상의 reference 논문

항체특이성 및 교차검증 연구와 자가항체 바이오마커 발굴, 단백질-단백질
결합 등 다양한 연구로 160편 이상의 논문이 발행되었습니다. 각종 보고서와
기술자료 등에도 널리 활용되고 있습니다.

연구보고서 샘플 다운로드

샘플 유형별 적용 분야

항체 샘플

항체특이성 및 교차반응 테스트
(Antibody Specificity & Cross-reactivity Test)

바이오시밀러-오리지널의 약품
동등성 비교 테스트

인간 혈청

혈청 프로파일링 : 질병특이적 면역
반응연구

자가면역질환 연구, 약물 반응성
연구 등

단백질 샘플

단백질-단백질 결합(Protein-Protein Interactions) 실험

소분자 물질

DNA, RNA, Peptide, Chemical 등의
샘플의 Human Protein Interactome
구축

Reference

Autoimmune Disease

Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Serological Autoantibody Repertoires and Autoantibody Associations with Disease Activity
Cunningham, K.Y., Hur, B., Gupta, V.K. et al. “Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity.” Sci Rep 13, 5360(2023). https://doi.org/10.1038/s41598-023-32428-4
Identification of Potential Autoantigens in Anti-CCP-positive and Anti-CCP-negative Rheumatoid Arthritis using Citrulline-specific Protein Arrays
Stensballe, Allan, Poulsen, Thomas B. G., et al. 2021. “Identification of Potential Autoantigens in Anti‐CCP‐positive and Anti‐CCP‐negative Rheumatoid Arthritis using Citrulline‐specific Protein Arrays.” Nature (2021) 11:17300 doi.org/10.1038/s41598-021-96675-z
Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA
Chen, Po-Ku, Joung-Liang Lan, Yi-Ming Chen, et al. 2021. “Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA.” Edited by Baohui Xu. Journal of Immunology Research 2021 (March): 1–13. doi:10.1155/2021/6656121
Detection of Putative Autoantibodies in Systemic Lupus Erythematous using a Novel Native-Conformation Protein Microarray Platform
Mak, Anselm, Nien Yee Kow, Nur Hafiza Ismail, et al. 2020. “Detection of Putative Autoantibodies in Systemic Lupus Erythematous Using a Novel Native-Conformation Protein Microarray Platform.” Lupus 29 (14): 1948–54.
doi:10.1177/0961203320959696
Identification of Novel Native Autoantigens in Rheumatoid Arthritis
Poulsen, Thomas B. G., Dres Damgaard, Malene Møller Jørgensen, et al. 2020.
“Identification of Novel Native Autoantigens in Rheumatoid Arthritis.” Biomedicines 8(6): 141. doi:10.3390/biomedicines8060141
Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus
Lewis, Myles J., Michael B. McAndrew, Colin Wheeler, et al. 2018. “Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus.” Journal of Autoimmunity 91 (July): 1–12. doi:10.1016/j.jaut.2018.02.009

Cancer

A Highly Predictive Autoantibody-based Biomarker Panel for Prognosis in Earlystage NSCLC with Potential Therapeutic Implications
Akshay J. Patel, Ti-Myen Tan, Alex G. Richter, Babu Naidu, Jonathan M. Blackburn and Gary W. Middleton. 2021. “A Highly Predictive Autoantibody-based Biomarker Panel for Prognosis in Early-stage NSCLC with Potential Therapeutic Implications” British Journal of Cancer. doi: 10.1038/s41416-021-01572-x
B Cells and Antibody Production in Melanoma
Da Gama Duarte, Jessica, Janique M. Peyper, and Jonathan M. Blackburn. 2018. “B Cells and Antibody Production in Melanoma.” Mammalian Genome 29 (11): 790–805. doi:10.1007/s00335-018-9778-z
A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma
Zaenker, Pauline, Johnny Lo, Robert Pearce, et al. 2018. “A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma.” Oncotarget 9 (55): 30539–51. doi:10.18632/oncotarget.25669.
Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma
Da Gama Duarte, Jessica, Sagun Parakh, Miles C. Andrews, et al. 2018.
“Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin Followed by Ipilimumab in Patients with Advanced Metastatic Melanoma.” Frontiers in Immunology 9. doi:10.3389/fimmu.2018.00411.
Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort
Adeola, Henry A., Muneerah Smith, Lisa Kaestner, et al. 2016. “Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort.” Oncotarget 7 (12): 13945–64. doi:10.18632/oncotarget.7359.
Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens
Beeton-Kempen, Natasha, Jessica Duarte, Aubrey Shoko, et al. 2014. “Development of a Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens.” International Journal of Cancer 135 (8): 1842–51. doi:10.1002/ijc.28832.
Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review
Zaenker, Pauline, and Melanie R. Ziman. 2013. “Serologic Autoantibodies as
Diagnostic Cancer Biomarkers—A Review.” Cancer Epidemiology and Prevention Biomarkers 22 (12): 2161–81. doi:10.1158/1055-9965.EPI-13-0621.
Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation
Duarte, Jessica, Jean-Michel Serufuri, Nicola Mulder, et al. 2013. “Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation.” In Bioinformatics of Human Proteomics, edited by Xiangdong Wang, 39–74. Translational Bioinformatics. Dordrecht: Springer Netherlands. doi:10.1007/978-94-007-5811-7_3
Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays
Gnjatic, Sacha, Colin Wheeler, Martin Ebner, et al. 2009. “Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors
Using Conformational Protein Arrays.” Journal of Immunological Methods 341 (1–2): 50–58. doi:10.1016/j.jim.2008.10.016
Functional Protein Microarrays for Parallel Characterisation of P53 Mutants
Boutell, Jonathan M., Darren J. Hart, Benjamin L. J. Godber, et al. 2004. “Functional Protein Microarrays for Parallel Characterisation of P53 Mutants.” PROTEOMICS 4(7): 1950–58. doi:https://doi.org/10.1002/pmic.200300722

Infectious Disease

Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies
Correlates with Protection against Re-Infection by New Variants in Subsequent
Waves of the COVID-19 Pandemic
Michelle O. Mullins, Muneerah Smith, Hazel Maboreke, Andrew J. M. Nel, Ntobeko A. B. Ntusi, Wendy A. Burgers and Jonathan M. Blackburn. 2023.Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates with Protection against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic. Viruses 2023,15,584. https://doi.org/ 10.3390/v15020584
Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein Variants in a Population of Black PLWH Vaccinated with ChAdOx1 nCoV-19
Muneerah Smith, Gaurav Kwatra, Alane Izu, Andrew Nel, Clare Cutland, Khatja
Ahmed, Vicky Baillie, Shaun Barnabas, Qasim Bhorat , Carmen Briner, Erica Lazarus, Keertan Dheda, Lee Fairlie, Anthonet Koen, Shabir Madhi and Jonathan M. Blackburn. 2023. Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein
Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort
Smith, M.; Abdesselem, H.B.; Mullins, M.; Tan, T.-M.; Nel, A.J.M.; Al-Nesf, M.A.Y.; Bensmail, I.; Majbour, N.K.; Vaikath, N.N.; Naik, A.; et al. Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort. Viruses 2021, 13, 786. https://doi.org/10.3390/ v13050786
Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform
Blackburn, Jonathan M, Nurdiana Anuar, Ti Myen Tan, et al. 2020. “Quantitative, Epitope-Specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-Based Immunoassay Platform.” Preprint. Infectious Diseases(except HIV/AIDS). doi:10.1101/2020.09.25.20201269
COVID-19 Antibody Testing: From Hype to Immunological Reality
Gray, C. M., J. Peter, M. Mendelson, et al. 2020. “COVID-19 Antibody Testing: From Hype to Immunological Reality.” South African Medical Journal 110 (9): 837–41
Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray
Soe, Hui, Yean Yong, Mazen M. Al-Obaidi, et al. 2018. “Identifying Protein
Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray.” Medicine 97 (5). doi:10.1097/MD.0000000000009713 Autoantibody Profile of Patients Infected with Knowlesi Malaria
Liew, Jonathan, Amirah Amir, Yeng Chen, et al. 2015. “Autoantibody Profile of Patients Infected with Knowlesi Malaria.” Clinica Chimica Acta; International Journal of Clinical Chemistry 448 (August): 33–38. doi:10.1016/j.cca.2015.06.006

Neurological Disease

Identification of Novel Candidate Autoantibodies in Alzheimer’s Disease
B. Z. Wang, F. Z. Zailan, et al. 2020. “Identification of Novel Candidate Autoantibodies in Alzheimer’s Disease.” European Journal of Neurology 2020, 27: 2292–2296. doi:10.1111/ene.14290
Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease
Patients May Be Linked to Greater Severity
Suwarnalata, Gunasekaran, Ai Huey Tan, Hidayah Isa, et al. 2016. “Augmentation of Autoantibodies by Helicobacter Pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity.” PloS One 11 (4): e0153725. doi:10.1371/journal.pone.0153725

Other Diseases

Peritoneal Autoantibody Profiling Identifies p53 as an Autoantibody Target in Endometriosis
Harden, S., Tan, T. Y., & Lee, Y. H. et al. 2023. “Peritoneal autoantibody profiling identifies p53 as an autoantibody target in endometriosis.” Fertility and Sterility® 2023 0015-0282 Copyright ©2023 American Society for Reproductive Medicine. https://doi.org/10.1016/j.fertnstert.2023.02.025
Novel Auto-antibodies in Idiopathic Small Fiber Neuropathy
Amanda CY Chan, Hiu Yi Wong, Yao Feng Chong, et al. 2021. “Novel Autoantibodies in Idiopathic Small Fiber Neuropathy” Annals of Neurology doi: 10.1002/ana.26268
Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified using an Immunomics Protein Array Technique
Chen, Chang-Hua, Ing-Lin Chang, Shu-Hui Wang, et al. 2020. “Potential Novel
Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified Using an Immunomics Protein Array Technique: Two Cases Reports.” Medicine 99 (43): e22852. doi:10.1097/MD.0000000000022852
A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from Beta-Thalassemia Major: A Pilot Study
Sumera, Afshan, Nur Diana Anuar, Ammu Kutty Radhakrishnan, et al. 2020. “A
Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from Beta-Thalassemia Major: A Pilot Study.” Biomedicines 8 (5): 97. doi:10.3390/biomedicines8050097

Technology

Pro-MAP: A Robust Pipeline for the Pre-processing of Single Channel Protein Microarray Data
Metoboroghene Oluwaseyi Mowoe, Shaun Garnett, Katherine Lennard, Jade Talbot, Paul Townsend, Eduard Jonas and Jonathan Michael Blackburn. 2022. “Pro-MAP: A Robust Pipeline for the Pre-processing of Single Channel Protein Microarray Data.” BMC Bioinformatics (2022) 23:534 https://doi.org/10.1186/s12859-022-05095-x
Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation
Aziz, Farhanah, Muneera Smith, and Jonathan M Blackburn. 2019. “Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation.” In Autoantibodies and Cytokines, edited by Wahid Ali Khan. IntechOpen. doi:10.5772/intechopen.75200
Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics
Aziz, Farhanah et al. 2018. “Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics.”
International Biopharmaceutical Industry 1(2). https://www.biopharmaceuticalmedia.com/applications-of-functional-proteinarrays-for-detection-and-development-of-autoantibody-based-diagnostic-andtherapeutic/
Advances in the Development of Human Protein Microarrays
Duarte, Jessica G., and Jonathan M. Blackburn. 2017. “Advances in the Development of Human Protein Microarrays.” Expert Review of Proteomics 14 (7):
627–41. doi:10.1080/14789450.2017.1347042
Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis
Blackburn, Jonathan M., and Aubrey Shoko. 2011. “Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis.” Methods in Molecular Biology(Clifton, N.J.) 785: 305–30. doi:10.1007/978-1-61779-286-1_21
Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays
Sacha Gnjatic, Colin Wheeler, Martin Ebner, Erika Ritter, Anne Murray, Nasser K.Altorki, Cathy A.Ferrara, Henry Hepburne-Scott, Sarah Joyce, Jens Koopman, Michael B.McAndrew, Nicholas Workman, Gerd Ritter, Rachel Fallon, Lloyd J.Old. 2009. “Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays.” Journal