임상 샘플에 최적화된 인간 1,800가지 단백질칩

새로운 Biomarkers를 발견하세요!

가능 샘플: 항체, Serum/Plasma, 단백질, 케미컬 등

임상에 최적화된 ‘잘 만든’
단백질 1,800종!

Well-folded 1,800가지 단백질로 임상 샘플 내의 다양한
auto-antibody 결합을 확인하세요.

모든 단백질이
Dual-spots으로

칩 상의 모든 단백질은 Dual spots, 즉 동일한 두 스팟으로 구성되어있으며, 한 번의 실험으로도 double checking이 가능합니다.

160건 이상의 reference 논문

항체특이성 및 교차검증 연구와 자가항체 바이오마커 발굴, 단백질-단백질
결합 등 다양한 연구로 160편 이상의 논문이 발행되었습니다. 각종 보고서와
기술자료 등에도 널리 활용되고 있습니다.

샘플 유형별 적용 분야

항체 샘플

항체특이성 및 교차반응 테스트
(Antibody Specificity & Cross-reactivity Test)

바이오시밀러-오리지널의 약품
동등성 비교 테스트

인간 혈청

혈청 프로파일링 : 질병특이적 면역
반응연구

자가면역질환 연구, 약물 반응성
연구 등

단백질 샘플

단백질-단백질 결합(Protein-Protein Interactions) 실험

소분자 물질

DNA, RNA, Peptide, Chemical 등의
샘플의 Human Protein Interactome
구축

Reference

Autoimmune Disease

  • Patients with ACPA-positive and ACPA-negative Rheumatoid Arthritis Show Different Serological Autoantibody Repertoires and Autoantibody Associations with Disease Activity
  • Cunningham, K.Y., Hur, B., Gupta, V.K. et al. “Patients with ACPA-positive and ACPA-negative rheumatoid arthritis show different serological autoantibody repertoires and autoantibody associations with disease activity.” Sci Rep 13, 5360(2023). https://doi.org/10.1038/s41598-023-32428-4
  • Identification of Potential Autoantigens in Anti-CCP-positive and Anti-CCP-negative Rheumatoid Arthritis using Citrulline-specific Protein Arrays
  • Stensballe, Allan, Poulsen, Thomas B. G., et al. 2021. “Identification of Potential Autoantigens in Anti‐CCP‐positive and Anti‐CCP‐negative Rheumatoid Arthritis using Citrulline‐specific Protein Arrays.” Nature (2021) 11:17300 doi.org/10.1038/s41598-021-96675-z
  • Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA
  • Chen, Po-Ku, Joung-Liang Lan, Yi-Ming Chen, et al. 2021. “Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA.” Edited by Baohui Xu. Journal of Immunology Research 2021 (March): 1–13. doi:10.1155/2021/6656121
  • Detection of Putative Autoantibodies in Systemic Lupus Erythematous using a Novel Native-Conformation Protein Microarray Platform
  • Mak, Anselm, Nien Yee Kow, Nur Hafiza Ismail, et al. 2020. “Detection of Putative Autoantibodies in Systemic Lupus Erythematous Using a Novel Native-Conformation Protein Microarray Platform.” Lupus 29 (14): 1948–54.
    doi:10.1177/0961203320959696
  • Identification of Novel Native Autoantigens in Rheumatoid Arthritis
  • Poulsen, Thomas B. G., Dres Damgaard, Malene Møller Jørgensen, et al. 2020.
    “Identification of Novel Native Autoantigens in Rheumatoid Arthritis.” Biomedicines 8(6): 141. doi:10.3390/biomedicines8060141
  • Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus
  • Lewis, Myles J., Michael B. McAndrew, Colin Wheeler, et al. 2018. “Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus.” Journal of Autoimmunity 91 (July): 1–12. doi:10.1016/j.jaut.2018.02.009

Cancer

  • A Highly Predictive Autoantibody-based Biomarker Panel for Prognosis in Earlystage NSCLC with Potential Therapeutic Implications
  • Akshay J. Patel, Ti-Myen Tan, Alex G. Richter, Babu Naidu, Jonathan M. Blackburn and Gary W. Middleton. 2021. “A Highly Predictive Autoantibody-based Biomarker Panel for Prognosis in Early-stage NSCLC with Potential Therapeutic Implications” British Journal of Cancer. doi: 10.1038/s41416-021-01572-x
  • B Cells and Antibody Production in Melanoma
  • Da Gama Duarte, Jessica, Janique M. Peyper, and Jonathan M. Blackburn. 2018. “B Cells and Antibody Production in Melanoma.” Mammalian Genome 29 (11): 790–805. doi:10.1007/s00335-018-9778-z
  • A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma
  • Zaenker, Pauline, Johnny Lo, Robert Pearce, et al. 2018. “A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma.” Oncotarget 9 (55): 30539–51. doi:10.18632/oncotarget.25669.
  • Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma
  • Da Gama Duarte, Jessica, Sagun Parakh, Miles C. Andrews, et al. 2018.
    “Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin Followed by Ipilimumab in Patients with Advanced Metastatic Melanoma.” Frontiers in Immunology 9. doi:10.3389/fimmu.2018.00411.
  • Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort
  • Adeola, Henry A., Muneerah Smith, Lisa Kaestner, et al. 2016. “Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort.” Oncotarget 7 (12): 13945–64. doi:10.18632/oncotarget.7359.
  • Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens
  • Beeton-Kempen, Natasha, Jessica Duarte, Aubrey Shoko, et al. 2014. “Development of a Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens.” International Journal of Cancer 135 (8): 1842–51. doi:10.1002/ijc.28832.
  • Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review
  • Zaenker, Pauline, and Melanie R. Ziman. 2013. “Serologic Autoantibodies as
    Diagnostic Cancer Biomarkers—A Review.” Cancer Epidemiology and Prevention Biomarkers 22 (12): 2161–81. doi:10.1158/1055-9965.EPI-13-0621.
  • Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation
  • Duarte, Jessica, Jean-Michel Serufuri, Nicola Mulder, et al. 2013. “Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation.” In Bioinformatics of Human Proteomics, edited by Xiangdong Wang, 39–74. Translational Bioinformatics. Dordrecht: Springer Netherlands. doi:10.1007/978-94-007-5811-7_3
  • Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays
  • Gnjatic, Sacha, Colin Wheeler, Martin Ebner, et al. 2009. “Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors
    Using Conformational Protein Arrays.” Journal of Immunological Methods 341 (1–2): 50–58. doi:10.1016/j.jim.2008.10.016
  • Functional Protein Microarrays for Parallel Characterisation of P53 Mutants
  • Boutell, Jonathan M., Darren J. Hart, Benjamin L. J. Godber, et al. 2004. “Functional Protein Microarrays for Parallel Characterisation of P53 Mutants.” PROTEOMICS 4(7): 1950–58. doi:https://doi.org/10.1002/pmic.200300722

Infectious Disease

  • Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies
    Correlates with Protection against Re-Infection by New Variants in Subsequent
    Waves of the COVID-19 Pandemic
  • Michelle O. Mullins, Muneerah Smith, Hazel Maboreke, Andrew J. M. Nel, Ntobeko A. B. Ntusi, Wendy A. Burgers and Jonathan M. Blackburn. 2023.Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates with Protection against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic. Viruses 2023,15,584. https://doi.org/ 10.3390/v15020584
  • Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein Variants in a Population of Black PLWH Vaccinated with ChAdOx1 nCoV-19
  • Muneerah Smith, Gaurav Kwatra, Alane Izu, Andrew Nel, Clare Cutland, Khatja
    Ahmed, Vicky Baillie, Shaun Barnabas, Qasim Bhorat , Carmen Briner, Erica Lazarus, Keertan Dheda, Lee Fairlie, Anthonet Koen, Shabir Madhi and Jonathan M. Blackburn. 2023. Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein
  • Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort
  • Smith, M.; Abdesselem, H.B.; Mullins, M.; Tan, T.-M.; Nel, A.J.M.; Al-Nesf, M.A.Y.; Bensmail, I.; Majbour, N.K.; Vaikath, N.N.; Naik, A.; et al. Age, Disease Severity and Ethnicity Influence Humoral Responses in a Multi-Ethnic COVID-19 Cohort. Viruses 2021, 13, 786. https://doi.org/10.3390/ v13050786
  • Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform
  • Blackburn, Jonathan M, Nurdiana Anuar, Ti Myen Tan, et al. 2020. “Quantitative, Epitope-Specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-Based Immunoassay Platform.” Preprint. Infectious Diseases(except HIV/AIDS). doi:10.1101/2020.09.25.20201269
  • COVID-19 Antibody Testing: From Hype to Immunological Reality
  • Gray, C. M., J. Peter, M. Mendelson, et al. 2020. “COVID-19 Antibody Testing: From Hype to Immunological Reality.” South African Medical Journal 110 (9): 837–41
  • Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray
  • Soe, Hui, Yean Yong, Mazen M. Al-Obaidi, et al. 2018. “Identifying Protein
    Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray.” Medicine 97 (5). doi:10.1097/MD.0000000000009713 Autoantibody Profile of Patients Infected with Knowlesi Malaria
  • Liew, Jonathan, Amirah Amir, Yeng Chen, et al. 2015. “Autoantibody Profile of Patients Infected with Knowlesi Malaria.” Clinica Chimica Acta; International Journal of Clinical Chemistry 448 (August): 33–38. doi:10.1016/j.cca.2015.06.006

Neurological Disease

  • Identification of Novel Candidate Autoantibodies in Alzheimer’s Disease
  • B. Z. Wang, F. Z. Zailan, et al. 2020. “Identification of Novel Candidate Autoantibodies in Alzheimer’s Disease.” European Journal of Neurology 2020, 27: 2292–2296. doi:10.1111/ene.14290
  • Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease
    Patients May Be Linked to Greater Severity
  • Suwarnalata, Gunasekaran, Ai Huey Tan, Hidayah Isa, et al. 2016. “Augmentation of Autoantibodies by Helicobacter Pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity.” PloS One 11 (4): e0153725. doi:10.1371/journal.pone.0153725

Other Diseases

  • Peritoneal Autoantibody Profiling Identifies p53 as an Autoantibody Target in Endometriosis
  • Harden, S., Tan, T. Y., & Lee, Y. H. et al. 2023. “Peritoneal autoantibody profiling identifies p53 as an autoantibody target in endometriosis.” Fertility and Sterility® 2023 0015-0282 Copyright ©2023 American Society for Reproductive Medicine. https://doi.org/10.1016/j.fertnstert.2023.02.025
  • Novel Auto-antibodies in Idiopathic Small Fiber Neuropathy
  • Amanda CY Chan, Hiu Yi Wong, Yao Feng Chong, et al. 2021. “Novel Autoantibodies in Idiopathic Small Fiber Neuropathy” Annals of Neurology doi: 10.1002/ana.26268
  • Potential Novel Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified using an Immunomics Protein Array Technique
  • Chen, Chang-Hua, Ing-Lin Chang, Shu-Hui Wang, et al. 2020. “Potential Novel
    Proteomic Biomarkers for Diagnosis of Vertebral Osteomyelitis Identified Using an Immunomics Protein Array Technique: Two Cases Reports.” Medicine 99 (43): e22852. doi:10.1097/MD.0000000000022852
  • A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from Beta-Thalassemia Major: A Pilot Study
  • Sumera, Afshan, Nur Diana Anuar, Ammu Kutty Radhakrishnan, et al. 2020. “A
    Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from Beta-Thalassemia Major: A Pilot Study.” Biomedicines 8 (5): 97. doi:10.3390/biomedicines8050097

Technology

  • Pro-MAP: A Robust Pipeline for the Pre-processing of Single Channel Protein Microarray Data
  • Metoboroghene Oluwaseyi Mowoe, Shaun Garnett, Katherine Lennard, Jade Talbot, Paul Townsend, Eduard Jonas and Jonathan Michael Blackburn. 2022. “Pro-MAP: A Robust Pipeline for the Pre-processing of Single Channel Protein Microarray Data.” BMC Bioinformatics (2022) 23:534 https://doi.org/10.1186/s12859-022-05095-x
  • Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation
  • Aziz, Farhanah, Muneera Smith, and Jonathan M Blackburn. 2019. “Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation.” In Autoantibodies and Cytokines, edited by Wahid Ali Khan. IntechOpen. doi:10.5772/intechopen.75200
  • Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics
  • Aziz, Farhanah et al. 2018. “Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics.”
    International Biopharmaceutical Industry 1(2). https://www.biopharmaceuticalmedia.com/applications-of-functional-proteinarrays-for-detection-and-development-of-autoantibody-based-diagnostic-andtherapeutic/
  • Advances in the Development of Human Protein Microarrays
  • Duarte, Jessica G., and Jonathan M. Blackburn. 2017. “Advances in the Development of Human Protein Microarrays.” Expert Review of Proteomics 14 (7):
    627–41. doi:10.1080/14789450.2017.1347042
  • Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis
  • Blackburn, Jonathan M., and Aubrey Shoko. 2011. “Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis.” Methods in Molecular Biology(Clifton, N.J.) 785: 305–30. doi:10.1007/978-1-61779-286-1_21
  • Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays
  • Sacha Gnjatic, Colin Wheeler, Martin Ebner, Erika Ritter, Anne Murray, Nasser K.Altorki, Cathy A.Ferrara, Henry Hepburne-Scott, Sarah Joyce, Jens Koopman, Michael B.McAndrew, Nicholas Workman, Gerd Ritter, Rachel Fallon, Lloyd J.Old. 2009. “Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays.” Journal

연구서비스 수행과정

STEP 1.

연구 설계 및 NDA 작성

  • 연구 컨설팅 및 학술 상담
  • 비밀유지/물질이전 계약
  • 전체 실험 스케줄 세팅

STEP 2. Microarray

preparation 및 샘플 전처리

  • Antigen specific peptides 계산
  • 컨펌 후 각각의 Peptides 합성
  • Peptides Microarray 제조

STEP 3.

본실험 및 분석

  • 샘플 송부 및 수령
  • 샘플 전처리 및 컨디션 확인
  • Go Epitope Mapping 수행

STEP 4.

보고서 작성 및 송부

  • 실험 결과 확인 및 데이터 마이닝
  • 종합 연구보고서 작성
  • 연구보고서 및 로데이터 송부

바텀 가로라인1

문의 사항이 있으신가요?

지금 바로 문의주세요!

바텀 가로라인2

전화상담
070-4712-9090
메일문의
info@geneon.kr
KAKAO TALK
CONTACT US
▲ TOP
tel:070-4712-9090
mailto:info@geneon.kr
https://pf.kakao.com/_TWxexhs/chat
/contact-us/