21,000 Human Proteins - GENE ON BIOTECH

Protein Binding Assay

More than 90% of All Human Proteins in One Chip!

Experience World-Class Proteomics Research.

Available Samples: Antibodies, Serum/Plasma, Proteins, Chemicals, etc.

It is contains 21,000 human proteins.
This is more than 90% of total number of human proteins.

Of the 22,000 proteins produced by approximately 22,000 human genes, more than 90% have been integrated into one array. Utilizing this into your experiment, you can quickly and accurately identify the human protein that the sample binds to.

Download Proteins List

All proteins have dual spots.

All proteins on a chip are comprised of dual spots. That is, two identical spots exist in each human protein. It is possible to examine the same dual phenomena in a single experiment.

More than 160 Reference Papers are Published.

All proteins on the chip are composed of dual spots. This means two things.

(1) Two identical spots are examined.

(2) Double checking is possible by a single experiment.

Download Research Report Sample

Application Areas by Sample Type

Antibody Sample

Antibody Specificity Test &
Cross Reactivity Test

Biosimilar-Original Drug
Equivalence Comparison Test

Human Serum

Serum Profiling:
Disease-Specific Immune Response Research

Autoimmune Disease Research,
Drug Reactivity Research, etc.

Protein Sample

Protein-Protein Interactions (PPIs) Experiment

Small Molecule

Human Protein Interactome Construction in Samples such as DNA, RNA, Peptide, Chemical, etc.

Reference

Antibody Specificity and Cross-reactivity

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Auto-antibody Biomarker Profiling

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Protein-Protein Interactions (PPIs)

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Kinase assays

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Other enzyme assays

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Nucleic Acid Binding

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Small molecule-Protein Interactions

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Other

Kim, Y et al (2019). Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Scientific Reports , Volume 9, Article number: 13495
Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nat Methods , in press
Ramos-López et al. (2018) Antibody Specificity Profiling using Protein Microarrays. In: Rockberg J., Nilvebrant J. (eds) Epitope Mapping Protocols, Methods in Molecular Biology, vol 1785. e0181251.
Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One 2017 Jul 31
Sterner E et al. (2017) Cell Rep 20(7):1681-1691 Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies.
Kim YP et al (2014) Effective Therapeutic Approach for Head and Neck Cancer by an Engineered Minibody Targeting the EGFR Receptor. PLoS One. 1;9(12):e113442.
Liu S et al. (2014) Characterization of monoclonal antibody’s binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119
Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253

Research Service Implementation Process

STEP 1.

Study Design and
NDA Writing

Research Consultation and Academic Consultation
Maintaining Confidentiality / Material Transfer Agreement
Setting Up the Entire Experiment Schedule

STEP 2. Microarray

Preparation and
Sample Pretreatment

Calculating Antigen Specific Peptides
Synthesizing Each Peptide after Confirmation
Producing Peptides Microarray

STEP 3.

Main Experiment and
Analysis

Sending and Receiving Samples
Preprocessing Samples and Checking Conditions
Performing Go Epitope Mapping

STEP 4.

Writing and
Sending Report

Confirming the Experiment Results and Data Mining
Writing a Comprehensive Research Report
Sending the Research Reports and the Raw Data

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